Why NAD+ is the limiting factor
Nicotinamide adenine dinucleotide (NAD+) is the coenzyme that mitochondria use to produce ATP and that sirtuins use to repair DNA. Human tissue NAD+ can fall by more than 50% between age 30 and 50 (Massudi et al., PLOS One, 2012). Restoring it is the foundational move in any serious longevity protocol.
NAD+ delivered directly (500 mg)
NAD+ Synergy provides 500 mg of NAD+ per 2-capsule serving — the coenzyme itself, not a precursor. This is the anchor of the formula.
Quercetin (250 mg) — the flavonoid antioxidant
Quercetin dihydrate from Sophora japonica flower bud contributes bioflavonoid antioxidant activity and is a traditional pairing with resveratrol in polyphenol research.
Resveratrol from Japanese Knotweed (150 mg, 98%)
Japanese Knotweed (Polygonum cuspidatum) is the highest-yield natural source of trans-resveratrol used in longevity research. The extract here is standardized to 98% resveratrol.
What NAD+ Synergy does NOT contain
For full transparency: NAD+ Synergy does not contain Nicotinamide Riboside (NR), NMN, CoQ10, PQQ or BioPerine®. It is a focused three-ingredient formula, not a multi-precursor stack.
- 01Yoshino M. et al., Cell Metabolism, 2021.
- 02Massudi H. et al., PLOS One, 2012.
- 03Howitz K. et al., Nature, 2003.
Editorial note: this article is provided for educational purposes and is not medical advice. Discuss supplementation with a qualified clinician, especially if you take prescription medication or have a medical condition.
